Article

Targeting acetyl-CoA metabolism attenuates the formation of fear memories through reduced activity-dependent histone acetylation

2022-05-22

Abstract excerpt

<h4>ABSTRACT</h4> Histone acetylation is a key component in the consolidation of long-term fear memories. Epigenetic enzymes involved in histone acetylation, including histone acetyltransferases and deacetylases, have been put forward as potential pharmacological targets in the treatment of pathological fear memories, such as those that underlie post-traumatic stress disorder (PTSD). However, these enzymes typica...

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Literature Corpus work: e7180b45-9d4e-5d47-ad31-1653834a122e
DOI: 10.1101/2022.05.22.492937

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