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HDAC inhibitors as cognitive enhancers in fear, anxiety and trauma therapy: where do we stand?

20 Mar 2014

Abstract excerpt

A novel strategy to treat anxiety and fear-related disorders such as phobias, panic and PTSD (post-traumatic stress disorder) is combining CBT (cognitive behavioural therapy), including extinction-based exposure therapy, with cognitive enhancers. By targeting and boosting mechanisms underlying learning, drug development in this field aims at designing CBT-augmenting compounds that help to overcome extinction...

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PMID: 24646280
DOI: 10.1042/bst20130233

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