Article
Estrogen-dependent association of HDAC4 with fear in female mice and women with PTSD.
Molecular psychiatry - 1 Mar 2018
Maddox S A, Kilaru V, Shin J, Jovanovic T, Almli L M, Dias B G, Norrholm S D, Fani N, Michopoulos V, Ding Z, Conneely K N, Binder E B, Ressler K J, Smith A K
Abstract excerpt
Women are at increased risk of developing post-traumatic stress disorder (PTSD) following a traumatic event. Recent studies suggest that this may be mediated, in part, by circulating estrogen levels. This study evaluated the hypothesis that individual variation in response to estrogen levels contributes to fear regulation and PTSD risk in women. We evaluated DNA methylation from blood of female participants in...
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