Article
Convergent translational evidence of a role for anandamide in amygdala-mediated fear extinction, threat processing and stress-reactivity.
Molecular psychiatry - 1 Jul 2013
Gunduz-Cinar O, MacPherson K P, Cinar R, Gamble-George J, Sugden K, Williams B, Godlewski G, Ramikie T S, Gorka A X, Alapafuja S O, Nikas S P, Makriyannis A, Poulton R, Patel S, Hariri A R, Caspi A, Moffitt T E, Kunos G, Holmes A
Abstract excerpt
Endocannabinoids are released 'on-demand' on the basis of physiological need, and can be pharmacologically augmented by inhibiting their catabolic degradation. The endocannabinoid anandamide is degraded by the catabolic enzyme fatty acid amide hydrolase (FAAH). Anandamide is implicated in the mediation of fear behaviors, including fear extinction, suggesting that selectively elevating brain anandamide could...
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