Article
ACSS2 mediates prenatal alcohol exposure-related morphological and behavioral phenotypes.
Neurobiology of disease - 1 Apr 2026
Dodson Kala M, Periandri Erica M, Yadav Anjali, Lopes Mariana, Barfield Amelia J, Ola Anjola, de Luna Vitorino Francisca N, Cearlock Cory, Garcia Benjamin A, Hill Cheryl A, Maloney Susan E, Egervari Gabor
Abstract excerpt
The metabolic enzyme Acetyl-CoA Synthetase 2 (ACSS2) recently emerged as an unexpected regulator of molecular and behavioral changes associated with alcohol use. Its role during prenatal exposure, however, remains unknown. Here, we use a combination of proteomic, genomic and behavioral approaches to establish ACSS2 as a key mediator of prenatal alcohol exposure-related phenotypes. We define the developmental...
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