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ACSS2 upregulation enhances neuronal resilience to aging and tau-associated neurodegeneration

2024-03-29

Abstract excerpt

<h4>ABSTRACT</h4> Epigenetic mechanisms, including histone acetylation, are pivotal for learning and memory, with a role in neuronal function in Alzheimer’s disease and Related Dementia (ADRD). Acetyl-CoA synthetase 2 (ACSS2), an enzyme that generates acetyl-CoA, is central to histone acetylation and gene regulation, particularly in neurons, due to their unique metabolic demands and postmitotic state. ACSS2 can b...

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Literature Corpus work
7f7d3d93-9e02-523e-b571-3ab68634d989
DOI
10.1101/2024.03.27.586865
Open publication

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ACSS2 upregulation enhances neuronal resilience to aging and tau-associated neurodegenerationDOI 10.1101/2024.03.27.586865
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