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An Essential Role for Histone Deacetylase 4 in Synaptic Plasticity and Memory Formation

8 Aug 2012

Abstract excerpt

Histone deacetylases (HDACs), a family of enzymes involved in epigenetic regulation, have been implicated in the control of synaptic plasticity, as well as learning and memory. Previous work has demonstrated administration of pharmacological HDAC inhibitors, primarily those targeted to class I HDACs, enhance learning and memory as well as long-term potentiation. However, a detailed understanding of the role of...

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PMID: 22875922
DOI: 10.1523/jneurosci.2089-12.2012

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