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Article

Aberrant histone deacetylase2-mediated histone modifications and synaptic plasticity in the amygdala predisposes to anxiety and alcoholism.

Biological psychiatry - 15 Apr 2013

Moonat Sachin, Sakharkar Amul J, Zhang Huaibo, Tang Lei, Pandey Subhash C

Abstract excerpt

BACKGROUND: Epigenetic mechanisms have been implicated in psychiatric disorders, including alcohol dependence. However, the epigenetic basis and role of specific histone deacetylase (HDAC) isoforms in the genetic predisposition to anxiety and alcoholism is unknown. METHODS: We measured amygdaloid HDAC activity, levels of HDAC isoforms, and histone H3 acetylation in selectively bred alcohol-preferring (P) and...

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Identifiers

PMID: 23485013
DOI: 10.1016/j.biopsych.2013.01.012
PMCID: PMC3718567

Genes

HDAC2

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