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Article

Dysregulation of Histone Acetylation in the APP/PS1 Mouse Model of Alzheimer's Disease

29 Jul 2009

Abstract excerpt

Epigenetic mechanisms such as post-translational histone modifications are increasingly recognized for their contribution to gene activation and silencing in the brain. Histone acetylation in particular has been shown to be important both in hippocampal long-term potentiation (LTP) and memory formation in mice. The involvement of the epigenetic modulation of memory formation has also been proposed in...

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PMID: 19625751
DOI: 10.3233/jad-2009-1134

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