Article

ACSS2 contributes to transcriptional regulation in Cajal-Retzius cells in a mouse model of Alzheimer’s disease

2024-04-12

Abstract excerpt

<h4>ABSTRACT</h4> Dysregulation of histone acetylation in the brain has emerged as a major contributor to human Alzheimer’s disease (AD). The mechanisms by which these protective or risk-conferring epigenetic marks are established and maintained are under intense investigation. ACSS2 (Acetyl-CoA Synthetase 2) is a key metabolic enzyme that is chromatin-associated in neurons. ACSS2 is recruited to specific promote...

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Literature Corpus work: 5358433f-a66f-5a4e-a864-6ecda1f46070
DOI: 10.1101/2024.04.08.588604

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