Article
Phenotype of circulating tumor-reactive T cells predicts immune checkpoint inhibitor response in non-small cell lung cancer.
Nature communications - 17 Feb 2026
Ito Katsuhiro, Iida Kei, Hirano Tomoko, Man Long Leong Merrin, Morii Kenji, Menju Toshi, Date Hiroshi, Ozasa Hiroaki, Yoshida Hironori, Hirai Toyohiro, Kawashima Shusuke, Aoyama Kazuhiro, Saeki Yuka, Inozume Takashi, Kobayashi Takashi, Chamoto Kenji, Yaguchi Tomonori
Abstract excerpt
Peripheral blood (PB) is a source of tumor-infiltrating tumor-reactive T cells (TR-T). Circulating TR-Ts (cTR-T) in PB are expected to contribute to the efficacy of immune checkpoint inhibitors (ICIs), but their phenotype remains poorly understood. Here we analyse paired tumor-infiltrating and peripheral CD8+ T cells from patients with non-small cell lung carcinoma (NSCLC), using single-cell RNA and T cell...
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