Article

Sensitivity to Immune Checkpoint Blockade and Progression-Free Survival is associated with baseline CD8 <sup>+</sup> T cell clone size and cytotoxicity

2020-11-16

Abstract excerpt

<h4>ABSTRACT</h4> Immune checkpoint blockers (ICB) exert their anti-cancer effects via CD8 + T cells, although how responses vary over sub-populations and across clones is incompletely understood. We performed single-cell RNA-sequencing of CD8 + T cells and their receptors pre- and post-ICB across eight patients, integrating results with bulk-sequencing data (n=209). We identify seven subsets with divergent res...

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Literature Corpus work: 4f51cf61-4c6d-5545-836f-a23473b3d2de
DOI: 10.1101/2020.11.15.383786

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