Article

Dynamic Tumor Immune Microenvironment Remodeling Predicts Response of Checkpoint Inhibitor Therapy

2024-07-02

Abstract excerpt

Immune checkpoint inhibitors (ICI) have transformed cancer therapy, yet the basis of variable patient responses remains unclear. We assembled a longitudinal single-cell RNA sequencing atlas of 441 samples from 241 patients across ten cancers to map treatment-associated remodeling of the tumor immune microenvironment (TIME). Using a hierarchical reference-guided deep-phenotyping framework, we defined 77 immune and...

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Literature Corpus work: 14c8798a-7af4-5640-aadf-81881b880808
DOI: 10.1101/2024.06.30.601413

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