Article

TSTScope Unifies Single-Cell Multi-Omics to Identify Functional T Cell States Predictive of Immunotherapy Response

2026-01-08

Abstract excerpt

<h4>ABSTRACT</h4> Immune checkpoint blockade (ICB) can produce durable responses in cancer, but reliable predictors of benefit are still lacking. CD8⁺ tumor-specific T cells are essential for ICB efficacy, yet it remains unclear which functional states of these cells determine therapeutic success. To address this, we developed TSTScope, an interpretable deep learning framework that integrates single-cell transcri...

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Literature Corpus work: 3afe9faa-a6ca-5ec1-9683-493920c2f8b5
DOI: 10.64898/2026.01.08.698283

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