Article
Endogenous retroviruses are a source of enhancers with oncogenic potential in acute myeloid leukaemia
2019-09-18
Abstract excerpt
Acute myeloid leukemia (AML) is a highly aggressive hematopoietic malignancy, defined by a series of genetic and epigenetic alterations, which result in deregulation of transcriptional networks. One understudied but important source of transcriptional regulators are transposable elements (TEs), which are widespread throughout the human genome. Aberrant usage of these sequences could therefore contribute to oncogen...
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Identifiers and source
- Literature Corpus work
- e6d317a0-5798-55a3-805f-8546aebfd26a
- DOI
- 10.1101/772954