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Article

Global Identification of EVI1 Target Genes in Acute Myeloid Leukemia

27 Jun 2013

Abstract excerpt

The ecotropic virus integration site 1 (EVI1) transcription factor is associated with human myeloid malignancy of poor prognosis and is overexpressed in 8-10% of adult AML and strikingly up to 27% of pediatric MLL-rearranged leukemias. For the first time, we report comprehensive genomewide EVI1 binding and whole transcriptome gene deregulation in leukemic cells using a combination of ChIP-Seq and RNA-Seq...

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PMID: 23826213
DOI: 10.1371/journal.pone.0067134

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Global Identification of EVI1 Target Genes in Acute Myeloid LeukemiaPMID 23826213Read ↗

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