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Article

EVI1 drives leukemogenesis through aberrant ERG activation

12 Sept 2022

Abstract excerpt

Chromosomal rearrangements involving the MDS1 and EVI1 complex locus (MECOM) on chromosome 3q26 define an aggressive subtype of acute myeloid leukemia (AML) that is associated with chemotherapy resistance and dismal prognosis. Established treatment regimens commonly fail in these patients, therefore, there is an urgent need for new therapeutic concepts that will require a better understanding of the molecular and...

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Identifiers

PMID: 36095844
DOI: 10.1182/blood.2022016592

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