Article

Endogenous retroviruses mediate transcriptional rewiring in response to oncogenic signaling in colorectal cancer

2021-10-30

Abstract excerpt

Cancer cells exhibit rewired transcriptional regulatory networks that promote tumor growth and survival. However, the mechanisms underlying the formation of these pathological networks remain poorly understood. Through a pan-cancer epigenomic analysis, we found that primate-specific endogenous retroviruses (ERVs) are a rich source of enhancers displaying cancer-specific activity. In colorectal cancer and other epi...

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Literature Corpus work: 8ed2bae9-c9e0-5c2a-a23a-2f43d9bf79f9
DOI: 10.1101/2021.10.28.466196

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