Article

Transposable Elements Shape Stemness in Normal and Leukemic Hematopoiesis

2021-02-17

Abstract excerpt

Despite most acute myeloid leukemia (AML) patients achieving complete remission after induction chemotherapy, two-thirds will relapse with fatal disease within five years. AML is organized as a cellular hierarchy sustained by leukemia stem cells (LSC) at the apex, with LSC properties directly linked to tumor progression, therapy failure, and disease relapse 1–5 . Despite the central role of LSC in poor patient ou...

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Literature Corpus work: 4a23a2df-b429-5dd3-9e6d-194752fdf646
DOI: 10.1101/2021.02.16.431334

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