Article

Epigenetic silencing of transposable elements by IRF2BP2 is a selective dependency of myeloid leukemia

2025-11-13

Abstract excerpt

Acute myeloid leukemia (AML) is a heterogeneous malignancy with limited curative treatment options. Transposable elements (TEs) are now recognized as key regulators of genome function, with aberrant activation implicated in cancer. However, their tumor-type-specific roles remain poorly characterized. Using single-cell Perturb-seq, we systematically screened for chromatin-associated regulators in primary AML patien...

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Literature Corpus work: 35312025-bc7a-5449-a2d4-397667ac76c1
DOI: 10.1101/2025.11.12.688028

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