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Article

Oncogenic Enhancers in Leukemia.

Blood cancer discovery - 3 Sept 2024

Mulet-Lazaro Roger, Delwel Ruud

Abstract excerpt

Although the study of leukemogenesis has traditionally focused on protein-coding genes, the role of enhancer dysregulation is becoming increasingly recognized. The advent of high-throughput sequencing, together with a better understanding of enhancer biology, has revealed how various genetic and epigenetic lesions produce oncogenic enhancers that drive transformation. These aberrations include translocations that...

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Identifiers

PMID: 39093124
DOI: 10.1158/2643-3230.BCD-23-0211
PMCID: PMC11369600

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