Article

Suppression of Transposable Elements in Leukemic Stem Cells

2017-07-28

Abstract excerpt

Genomic transposable elements (TEs) comprise nearly half of the human genome. The expression of TEs is considered potentially hazardous, as it can lead to insertional mutagenesis and genomic instability. However, recent studies have revealed that TEs are involved in immune-mediated cell clearance. Hypomethylating agents can increase the expression of TEs in cancer cells, inducing ‘viral mimicry’, causing interfero...

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Literature Corpus work: 80c0b681-9e0f-5c8f-9acb-68efec747030
DOI: 10.1101/169524

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