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Article

Transcriptional dysregulation by aberrant enhancer activation and rewiring in cancer.

Cancer science - 1 Jun 2021

Okabe Atsushi, Kaneda Atsushi

Abstract excerpt

Cell identity is controlled by regulatory elements, such as promoters, enhancers, and insulators, within the genome. These regulatory elements interact in the nucleus and form tissue-specific chromatin structures. Dysregulation of these elements and their interactions can lead to loss of cell identity and promote the development of diseases such as cancer. Tumor cells acquire aberrantly activated enhancers at...

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Share to Chromatin
Share to Enhancer Elements, Genetic
Share to Epigenesis, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Neoplastic

Share to Oncogenes

Share to Retroviridae Infections

Share to Transcriptional Activation

Share to Translocation, Genetic

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Identifiers

PMID: 33728716
DOI: 10.1111/cas.14884
PMCID: PMC8177786

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