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Article

A Novel Human Cytomegalovirus Locus Modulates Cell Type-Specific Outcomes of Infection

29 Dec 2011

Abstract excerpt

Clinical strains of HCMV encode 20 putative ORFs within a region of the genome termed ULb' that are postulated to encode functions related to persistence or immune evasion. We have previously identified ULb'-encoded pUL138 as necessary, but not sufficient, for HCMV latency in CD34+ hematopoietic progenitor cells (HPCs) infected in vitro. pUL138 is encoded on polycistronic transcripts that also encode 3 additional...

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PMID: 22241980
DOI: 10.1371/journal.ppat.1002444

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