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Antagonistic Determinants Controlling Replicative and Latent States of Human Cytomegalovirus Infection

13 Mar 2014

Abstract excerpt

UNLABELLED: The mechanisms by which viruses persist and particularly those by which viruses actively contribute to their own latency have been elusive. Here we report the existence of opposing functions encoded by genes within a polycistronic locus of the human cytomegalovirus (HCMV) genome that regulate cell type-dependent viral fates: replication and latency. The locus, referred to as the UL133-UL138 (UL133/8)...

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PMID: 24623432
DOI: 10.1128/jvi.03506-13

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