Article

Viral and host network analysis of the human cytomegalovirus transcriptome in latency

2024-05-21

Abstract excerpt

HCMV genes UL135 and UL138 play opposing roles regulating latency and reactivation in CD34 + human progenitor cells (HPCs). Using the THP-1 cell line model for latency and reactivation, we designed an RNA sequencing study to compare the transcriptional profile of HCMV infection in the presence and absence of these genes. The loss of UL138 results in elevated levels of viral gene expression and increased differ...

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Literature Corpus work: e9ac2562-e747-5bfb-9df4-54fbafc4b2ff
DOI: 10.1101/2024.05.21.594597

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