Article

LXR-inducible host E3 ligase IDOL targets a human cytomegalovirus reactivation determinant

2022-11-16

Abstract excerpt

<h4>Summary</h4> Liver X receptor (LXR) signaling broadly restricts virus replication; however, the mechanisms of restriction are poorly defined. Here, we demonstrate that the LXR-inducible cellular E3 ligase IDOL (inducible degrader of low-density lipoprotein receptor, LDLR) targets the human cytomegalovirus (HMCV) UL136p33 protein for turnover. UL136 encodes multiple proteins that differentially impact latency...

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Identifiers and source

Literature Corpus work: c954d6dc-16b3-5bf7-8e3f-e5f593100022
DOI: 10.1101/2022.11.15.516687

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