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Viral and host network analysis of the human cytomegalovirus transcriptome in latency

28 May 2025

Abstract excerpt

The human cytomegalovirus (HCMV) UL135 and UL138 genes play opposing roles regulating latency and reactivation in CD34 + human progenitor cells. We designed an RNA sequencing study to compare the transcriptional profile of HCMV infection in the presence and absence of these genes using the Tohoku Hospital Pediatrics-1 (THP-1) monocytic cell line model for latency. Relative to primary cell models, THP-1 cells...

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PMID: 40434638
DOI: 10.1073/pnas.2416114122

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