Article

Carm1 regulates the speed of C/EBPα-induced transdifferentiation by a cofactor stealing mechanism

2022-10-04

Abstract excerpt

<h4>ABSTRACT</h4> Cell fate decisions are driven by lineage-restricted transcription factors but how they are regulated is incompletely understood. The C/EBPα-induced B cell to macrophage transdifferentiation (BMT) is a powerful system to address this question. Here we describe that C/EBPα with a single arginine mutation (C/EBPα R35A ) induces a dramatically accelerated BMT in mouse and human cells. Changes in t...

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Literature Corpus work: e69644ee-41bf-5658-93ed-b34b142fc3d2
DOI: 10.1101/2022.10.03.510647

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