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Article

A C/ebpα isoform specific differentiation program in immortalized myelocytes.

Leukemia - 1 Sept 2023

Garcia-Cuellar Maria-Paz, Akan Selin, Slany Robert K

Abstract excerpt

The transcription factor CCAAT-enhancer binding factor alpha (C/ebpα) is a master controller of myeloid differentiation that is expressed as long (p42) and short (p30) isoform. Mutations within the CEBPA gene selectively deleting p42 are frequent in human acute myeloid leukemia. Here we investigated the individual genomics and transcriptomics of p42 and p30. Both proteins bound to identical sites across the...

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Identifiers

PMID: 37532789
DOI: 10.1038/s41375-023-01989-8
PMCID: PMC10457184

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