A C-terminal mutant of CCAAT-enhancer-binding protein α (C/EBPα-Cm) downregulates Csf1r, a potent accelerator in the progression of acute myeloid leukemia with C/EBPα-Cm.

doi:10.1016/j.exphem.2014.11.011

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A C-terminal mutant of CCAAT-enhancer-binding protein α (C/EBPα-Cm) downregulates Csf1r, a potent accelerator in the progression of acute myeloid leukemia with C/EBPα-Cm.

Experimental hematology - 1 Apr 2015

Togami Katsuhiro, Kitaura Jiro, Uchida Tomoyuki, Inoue Daichi, Nishimura Koutarou, Kawabata Kimihito C, Nagase Reina, Horikawa Sayuri, Izawa Kumi, Fukuyama Tomofusa, Nakahara Fumio, Oki Toshihiko, Harada Yuka, Harada Hironori, Aburatani Hiroyuki, Kitamura Toshio

Abstract excerpt

Two types of CCAAT-enhancer-binding protein α (C/EBPα) mutants are found in acute myeloid leukemia (AML) patients: N-terminal frame-shift mutants (C/EBPα-N(m)) generating p30 as a dominant form and C-terminal basic leucine zipper domain mutants (C/EBPα-C(m)). We have previously shown that C/EBPα-K304_R323dup belonging to C/EBPα-C(m), but not C/EBPα-T60fsX159 belonging to C/EBPα-N(m), alone induced AML in mouse...

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PMID: 25534203
DOI: 10.1016/j.exphem.2014.11.011

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