Article

Alu-mediated weak CEBPA binding and slow B cell transdifferentiation in human

2021-10-29

Abstract excerpt

Many developmental and differentiation processes take substantially longer in human than in mouse. To investigate the molecular mechanisms underlying this phenomenon, here we have specifically focused on the transdifferentiation from B cells to macrophages. The process is triggered by exactly the same molecular mechanism -- the induction by the transcription factor (TF) CEBPA -- but takes three days in mouse and s...

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Literature Corpus work: bf31ab27-d254-57b6-8a3d-8daac2b45af2
DOI: 10.1101/2021.10.28.466072

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