Article

Arginine methylation of the p30 C/EBPα oncoprotein regulates progenitor proliferation and myeloid differentiation

2024-03-30

Abstract excerpt

<h4>ABSTRACT</h4> The transcription factor CCAAT enhancer binding protein alpha (C/EBPα) is a master regulator of myelopoiesis. CEBPA encodes a long (p42) and a truncated (p30) protein isoform from a single mRNA. Mutations that abnormally enhance expression of p30 are associated with acute myelogenous leukemia (AML). We show by mutational analysis that three highly conserved arginine residues (R140,147,154) loca...

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Literature Corpus work: 122a0106-ad45-535c-ac4f-35dc769ec273
DOI: 10.1101/2024.03.28.587207

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