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Article

Role of transcription factors C/EBPalpha and PU.1 in normal hematopoiesis and leukemia.

International journal of hematology - 1 Jun 2005

Koschmieder Steffen, Rosenbauer Frank, Steidl Ulrich, Owens Bronwyn M, Tenen Daniel G

Abstract excerpt

Differentiation of hematopoietic stem and progenitor cells is under strict control of a regulatory network orchestrated by lineage-specific transcription factors. A block in normal differentiation is a major contributing factor in the development of solid tumors and leukemias. Cells from patients with acute myeloid leukemia (AML) frequently harbor mutated or dysregulated transcription factor genes, suggesting...

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Source

Identifiers

PMID: 16158816
DOI: 10.1532/ijh97.05051

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Role of transcription factors C/EBPalpha and PU.1 in normal hematopoiesis and leukemia.PMID 16158816Read ↗

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