Role of transcription factors C/EBPalpha and PU.1 in normal hematopoiesis and leukemia.

doi:10.1532/ijh97.05051

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Article

Role of transcription factors C/EBPalpha and PU.1 in normal hematopoiesis and leukemia.

International journal of hematology - 1 Jun 2005

Koschmieder Steffen, Rosenbauer Frank, Steidl Ulrich, Owens Bronwyn M, Tenen Daniel G

Abstract excerpt

Differentiation of hematopoietic stem and progenitor cells is under strict control of a regulatory network orchestrated by lineage-specific transcription factors. A block in normal differentiation is a major contributing factor in the development of solid tumors and leukemias. Cells from patients with acute myeloid leukemia (AML) frequently harbor mutated or dysregulated transcription factor genes, suggesting...

Topics

Activating Transcription Factor 2
Animals
Cyclic AMP Response Element-Binding Protein
Gene Expression Regulation
Hematopoiesis
Humans
Leukemia
Mice
Mutation
Proto-Oncogene Proteins
Trans-Activators
Transcription Factors

Source

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Identifiers

PMID: 16158816
DOI: 10.1532/ijh97.05051

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