Article

A new type of transcriptional reprogramming by an IRF4 mutation in lymphoma

2022-12-29

Abstract excerpt

<h4>SUMMARY PARAGRAPH</h4> Disease-causing mutations in genes encoding transcription factors (TFs) are a recurrent finding in hematopoietic malignancies and might involve key regulators of lineage adherence and cellular differentiation 1–3 . Such mutations can affect TF-interactions with their cognate DNA-binding motifs 4, 5 . Whether and how TF-mutations impact upon the nature of binding to TF composite elemen...

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Literature Corpus work: 9a0464c7-f78d-5619-b633-82bde72772d0
DOI: 10.1101/2022.12.29.522203

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