Article
The AML-associated K313 mutation enhances C/EBPα activity by leading to C/EBPα overexpression.
Cell death & disease - 5 Jul 2021
Gentle Ian Edward, Moelter Isabel, Badr Mohamed Tarek, Döhner Konstanze, Lübbert Michael, Häcker Georg
Abstract excerpt
Mutations in the transcription factor C/EBPα are found in ~10% of all acute myeloid leukaemia (AML) cases but the contribution of these mutations to leukemogenesis is incompletely understood. We here use a mouse model of granulocyte progenitors expressing conditionally active HoxB8 to assess the cell biological and molecular activity of C/EBPα-mutations associated with human AML. Both N-terminal truncation and...
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