Article

Biophysical Principles of Lineage Factor PU.1 Binding Revealed by NextPBMs

2018-05-22

Abstract excerpt

<h4>ABSTRACT</h4> Determining the biophysical principles that shape transcription factor (TF) binding in a cell-specific manner is key to quantitative models of gene expression. High-throughput (HT) in vitro methods measuring protein-DNA binding are invaluable for relating TF binding affinity to genome-wide binding; however, the impact of cell-specific post-translational modifications (PTMs) and cofactors are no...

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Literature Corpus work: f78e30e0-d738-5e5e-8ec7-d29d895f0a39
DOI: 10.1101/328625

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