Article

Absolute quantification of transcription factors reveals principles of gene regulation in erythropoiesis

2019-10-21

Abstract excerpt

<h4>Summary</h4> Dynamic cellular processes such as differentiation are driven by changes in the abundances of transcription factors (TFs). Yet, despite years of studies we still do not know the protein copy number of TFs in the nucleus. Here, by determining the absolute abundances of 103 TFs and co-factors during the course of human erythropoiesis, we provide a dynamic and quantitative scale for TFs in the nucle...

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Literature Corpus work: cdd89832-470c-54eb-aa2d-49a8c0bc3a6c
DOI: 10.1101/812123

Open publication

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