Article

Single cell transcriptomic profiling of tauopathy in a novel 3D neuron-astrocyte coculture model

2022-05-04

Abstract excerpt

<h4>ABSTRACT</h4> The use of iPSC derived brain organoid models to study neurodegenerative disease has been hampered by a lack of systems that accurately and expeditiously recapitulate pathogenesis in the context of neuron-glial interactions. Here we report development of a system, termed AstTau, which propagates toxic human tau oligomers in iPSC derived neuron-astrocyte spheroids. The AstTau system develops much...

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Literature Corpus work: e67d1a50-ab11-5d36-b01c-0d1053d596fa
DOI: 10.1101/2022.05.03.490513

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