Article

Determinants of Astrocytic Pathology in Stem Cell Models of Primary Tauopathies

2023-07-19

Abstract excerpt

<h4>ABSTRACT</h4> Astrocytic tau aggregates are seen in several primary and secondary tauopathies, including progressive supranuclear palsy (PSP), corticobasal degeneration (CBD), and chronic traumatic encephalopathy (CTE). In all cases, astrocytic tau consists exclusively of the longer (4R) tau isoform, even when adjacent neuronal aggregates consist of a mixture of 3- and 4R tau, as in CTE. The reasons for this...

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Literature Corpus work: 80d2927e-3249-51d1-8121-3f764994c8e0
DOI: 10.1101/2023.07.18.549558

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