Article

Single cell transcriptomic profiling of neurodegeneration mediated by tau propagation in a novel 3D neuron-astrocyte coculture model

2021-03-01

Abstract excerpt

<title>Abstract</title> <p>Research into neurodegeneration has been hampered by lack of systems that accurately recapitulate neurodegenerative processes1. Propagation of tau through a ‘prion-like’ process has emerged as an important aspect of neurodegenerative diseases including Alzheimer’s disease2. However, molecular mechanism of tau propagation is still largely unknown and a human 3D cellular model is still la...

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Literature Corpus work: a56a996d-1489-5122-ba49-344c7dc0ea39
DOI: 10.21203/rs.3.rs-263918/v1

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