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Article

Astrocyte pathology in a human neural stem cell model of frontotemporal dementia caused by mutant TAU protein.

Scientific reports - 3 Mar 2017

Hallmann Anna-Lena, Araúzo-Bravo Marcos J, Mavrommatis Lampros, Ehrlich Marc, Röpke Albrecht, Brockhaus Johannes, Missler Markus, Sterneckert Jared, Schöler Hans R, Kuhlmann Tanja, Zaehres Holm, Hargus Gunnar

Abstract excerpt

Astroglial pathology is seen in various neurodegenerative diseases including frontotemporal dementia (FTD), which can be caused by mutations in the gene encoding the microtubule-associated protein TAU (MAPT). Here, we applied a stem cell model of FTD to examine if FTD astrocytes carry an intrinsic propensity to degeneration and to determine if they can induce non-cell-autonomous effects in neighboring neurons. We...

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Identifiers

PMID: 28256506
DOI: 10.1038/srep42991
PMCID: PMC5335603

Genes

MAPT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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