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Engineered Cerebral Organoids Recapitulate Adult Tau Expression and Disease-relevant Changes in Tau Splicing

2020-06-30

Abstract excerpt

<title>Abstract</title> <p>The tauopathies are a collection of clinically and pathologically diverse neurodegenerative disorders characterised by tau pathology. The tau protein exists as multiple protein isoforms in the adult human CNS, generated by alternative splicing of the <italic>MAPT </italic>gene. Disruptions to tau splicing are associated with a number of tauopathies, however, <italic>in vitro</italic> an...

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Literature Corpus work
7fd2325b-45d5-5e76-a93b-eb342a5feaf7
DOI
10.21203/rs.3.rs-37620/v1
Open publication

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