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Article

Systematic analysis of functional genetic and epigenetic variants in colorectal cancer.

Science advances - 20 Feb 2026

Chen Erfei, Yang Qiqi, Dai Haoyang, Chen Yixin, Zhang Yihui, Wang Qianglong, Hou Rongrong, Chen Ming, Wang Jie, Xie Qianwen, Sun Wenju, Ning Yong-Qiang, Fan Ligang, Yan Jian

Abstract excerpt

Colorectal cancer (CRC) is a leading cause of cancer-related mortality worldwide, yet the functional impact of noncoding variants on enhancer activity remains largely unexplored. In this study, we adapted and applied two high-throughput techniques, SNP-STARR-seq and Methyl-STARR-seq, to systematically evaluate the influence of 30,790 noncoding SNPs and more than 134,000 CpG sites on enhancer activity in primary...

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Share to Cell Line, Tumor
Share to Colorectal Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Enhancer Elements, Genetic

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Share to Gene Expression Regulation, Neoplastic

Share to Polymorphism, Single Nucleotide

Source

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Identifiers

PMID: 41719390
DOI: 10.1126/sciadv.aeb2473
PMCID: PMC12922747

Genes

ETV3
KIRREL1
RUNX2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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