Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Characterization of cis-regulatory elements and functional variants in colorectal cancer using epigenomics and CRISPRi screenings.

Nature cancer - 1 Nov 2025

Lu Zequn, Chen Can, Zhang Heng, Li Bin, Liu Yizhuo, Guo Jiayi, Xu Runying, Shi Ke, Ma Qianying, Zhang Ming, Cai Yimin, Huang Jinyu, Geng Hui, Fan Linyun, Ning Caibo, Li Yanmin, Chen Shuoni, Tian Wen, Hu Kexin, Li Haijie, Yang Xiaojun, Huang Chaoqun, Wei Yongchang, Zhu Xu, Li Xiangpan, Xiong Zhen, Cai Ming, Wang Xiaoyang, Zhang Shaokai, Chen Hongda, Dai Min, Chen Kun, Jin Mingjuan, Jin Meng, Zhu Ying, Tian Jianbo, Miao Xiaoping

Abstract excerpt

Genetic variants associated with colorectal cancer (CRC) are primarily noncoding and reside in cis-regulatory elements (CREs), yet their underlying mechanisms remain elusive. Here we established a dynamic epigenetic atlas using multiomics data from 533 colorectal tissues spanning normal to advanced adenoma to cancer, identifying 7,492 differential CREs linked to 5,490 target genes. High-throughput CRISPR...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Colorectal Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to CRISPR-Cas Systems

Share to Epigenesis, Genetic

Share to Epigenomics

Share to Gene Expression Regulation, Neoplastic

Share to Regulatory Sequences, Nucleic Acid

Share to Repressor Proteins

Share to Transcription Factor 7-Like 2 Protein

Source

Identifiers

PMID: 40854986
DOI: 10.1038/s43018-025-01031-z

Genes

FOXP1
KLF5
PIBF1
TCF7L2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Characterization of cis-regulatory elements and functional variants in colorectal cancer using epigenomics and CRISPRi screenings.PMID 40854986Read ↗

Systematic analysis of functional genetic and epigenetic variants in colorectal cancer.Semantic proximity Read ↗

Enhancer-gene regulatory interactions in colorectal cancer revealed through genome-wide CRISPRi perturbationsSemantic proximity Read ↗

Functional annotation of colon cancer risk SNPs.Semantic proximity Read ↗

Systematic prioritization of functional variants and effector genes underlying colorectal cancer risk.Semantic proximity Read ↗

Deciphering colorectal cancer genetics through multi-omic analysis of 100,204 cases and 154,587 controls of European and east Asian ancestries.Semantic proximity Read ↗

Genetic variation at 11q23.1 confers colorectal cancer risk by dysregulation of colonic tuft cell transcriptional activator <i>POU2AF2</i>Semantic proximity Read ↗

Fine-mapping analysis including over 254,000 East Asian and European descendants identifies 136 putative colorectal cancer susceptibility genes.Semantic proximity Read ↗

Molecular characterization of colorectal adenomas with and without malignancy reveals distinguishing genome, transcriptome and methylome alterationsSemantic proximity Read ↗

Precision CRISPR annotation of the functional enhancer landscape in primary human T cellsSemantic proximity Read ↗

Genome-wide profiling of active enhancers in colorectal cancerSemantic proximity Read ↗

Hotspots of aberrant enhancer activity punctuate the colorectal cancer epigenome.Semantic proximity Read ↗

Genetic variation at 11q23.1 confers colorectal cancer risk by dysregulation of colonic tuft cell transcriptional activator POU2AF2Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.