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Article

Rapid progression to glioblastoma in a subset of IDH-mutated astrocytomas: a genome-wide analysis.

Journal of neuro-oncology - 1 May 2017

Richardson Timothy E, Snuderl Matija, Serrano Jonathan, Karajannis Matthias A, Heguy Adriana, Oliver Dwight, Raisanen Jack M, Maher Elizabeth A, Pan Edward, Barnett Samuel, Cai Chunyu, Habib Amyn A, Bachoo Robert M, Hatanpaa Kimmo J

Abstract excerpt

According to the recently updated World Health Organization (WHO) classification (2016), grade II-III astrocytomas are divided into IDH-wildtype and IDH-mutant groups, the latter being significantly less aggressive in terms of both progression-free and total survival. We identified a small cohort of WHO grade II-III astrocytomas that harbored the IDH1 R132H mutation, as confirmed by both immunohistochemistry and...

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Source

Identifiers

PMID: 28421459
DOI: 10.1007/s11060-017-2431-y

Genes

IDH1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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