Single-cell multimodal glioma analyses identify epigenetic regulators of cellular plasticity and environmental stress response.

doi:10.1038/s41588-021-00926-8

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Single-cell multimodal glioma analyses identify epigenetic regulators of cellular plasticity and environmental stress response.

Nature genetics - 1 Oct 2021

Johnson Kevin C, Anderson Kevin J, Courtois Elise T, Gujar Amit D, Barthel Floris P, Varn Frederick S, Luo Diane, Seignon Martine, Yi Eunhee, Kim Hoon, Estecio Marcos R H, Zhao Dacheng, Tang Ming, Navin Nicholas E, Maurya Rahul, Ngan Chew Yee, Verburg Niels, de Witt Hamer Philip C, Bulsara Ketan, Samuels Michael L, Das Sunit, Robson Paul, Verhaak Roel G W

Abstract excerpt

Glioma intratumoral heterogeneity enables adaptation to challenging microenvironments and contributes to therapeutic resistance. We integrated 914 single-cell DNA methylomes, 55,284 single-cell transcriptomes and bulk multi-omic profiles across 11 adult IDH mutant or IDH wild-type gliomas to delineate sources of intratumoral heterogeneity. We showed that local DNA methylation disorder is associated with cell-cell...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Brain Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Plasticity

Share to Clonal Evolution

Share to Genetic Heterogeneity

Share to Glioma

Share to Single-Cell Analysis

Share to Stress, Physiological

Share to Tumor Microenvironment

Source

Open in PubMed Open full text

Identifiers

PMID: 34594038
DOI: 10.1038/s41588-021-00926-8
PMCID: PMC8570135

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Single-cell multimodal glioma analyses identify epigenetic regulators of cellular plasticity and environmental stress response.PMID 34594038Read ↗

Single-cell multimodal glioma analyses reveal epigenetic regulators of cellular plasticity and environmental stress responseSemantic proximity Read ↗

The epigenetic evolution of gliomas is determined by their IDH1 mutation status and treatment regimenSemantic proximity Read ↗

Longitudinal changes in DNA methylation in IDH-mutant glioma fuel disease progression through altered cell state differentiation.Semantic proximity Read ↗

The Epigenetic Evolution of Glioma Is Determined by the IDH1 Mutation Status and Treatment Regimen.Semantic proximity Read ↗

Spatiotemporal heterogeneity of glioblastoma is dictated by microenvironmental interferenceSemantic proximity Read ↗

Genetic and epigenetic instability as an underlying driver of progression and aggressive behavior in IDH-mutant astrocytoma.Semantic proximity Read ↗

DNA methylation variability defines a fundamental dimension of tumor epigenomes linked to genomic instability, tumor aggressiveness, and clinical outcomesSemantic proximity Read ↗

Spatiotemporal heterogeneity of glioblastoma is dictated by microenvironmental interferenceSemantic proximity Read ↗

Microenvironment-Driven Dynamic Chromatin Changes in Glioblastoma Recapitulate Early Neural Development at Single-Cell ResolutionSemantic proximity Read ↗

Single-nucleus multiomics unveils malignant cellular states, regulatory architectures and microenvironmental reorganization across the G-CIMP epigenomic transition in IDH-mutant gliomaSemantic proximity Read ↗

Intratumor heterogeneity in epigenetic patternsSemantic proximity Read ↗

Mutant-IDH1-dependent chromatin state reprogramming, reversibility, and persistence.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.