Article
The IDH1 Mutation-Induced Oncometabolite, 2-Hydroxyglutarate, May Affect DNA Methylation and Expression of PD-L1 in Gliomas
28 Mar 2018
Abstract excerpt
Background: Malignant gliomas are heterogeneous brain tumors with the potential for aggressive disease progression, as influenced by suppressive immunoediting. Given the success and enhanced potential of immune-checkpoint inhibitors in glioma immunotherapy, we focused on the connections between genetic alterations affected by IDH1 mutations with immunological landscape changes. Methods: Paired, surgically...
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