Article
Glioma progression is shaped by genetic evolution and microenvironment interactions.
Cell - 9 Jun 2022
Varn Frederick S, Johnson Kevin C, Martinek Jan, Huse Jason T, Nasrallah MacLean P, Wesseling Pieter, Cooper Lee A D, Malta Tathiane M, Wade Taylor E, Sabedot Thais S, Brat Daniel, Gould Peter V, Wöehrer Adelheid, Aldape Kenneth, Ismail Azzam, Sivajothi Santhosh K, Barthel Floris P, Kim Hoon, Kocakavuk Emre, Ahmed Nazia, White Kieron, Datta Indrani, Moon Hyo-Eun, Pollock Steven, Goldfarb Christine, Lee Ga-Hyun, Garofano Luciano, Anderson Kevin J, Nehar-Belaid Djamel, Barnholtz-Sloan Jill S, Bakas Spyridon, Byrne Annette T, D'Angelo Fulvio, Gan Hui K, Khasraw Mustafa, Migliozzi Simona, Ormond D Ryan, Paek Sun Ha, Van Meir Erwin G, Walenkamp Annemiek M E, Watts Colin, Weiss Tobias, Weller Michael, Palucka Karolina, Stead Lucy F, Poisson Laila M, Noushmehr Houtan, Iavarone Antonio, Verhaak Roel G W
Abstract excerpt
The factors driving therapy resistance in diffuse glioma remain poorly understood. To identify treatment-associated cellular and genetic changes, we analyzed RNA and/or DNA sequencing data from the temporally separated tumor pairs of 304 adult patients with isocitrate dehydrogenase (IDH)-wild-type and IDH-mutant glioma. Tumors recurred in distinct manners that were dependent on IDH mutation status and...
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