Article

Actionable spatial prostanoid barriers constrain BiTE-driven adoptive T cell immunity in intact human tumors

2026-03-30

Abstract excerpt

Adoptive cell therapy (ACT) in solid tumors is limited by tumor microenvironment (TME)-imposed resistance mechanisms that are inadequately addressed by conventional systems. We developed tissue-preserving patient-derived explants (PDEs) from lung and ovarian cancer to interrogate redirected T cell immunity in intact human tissue. Using mesothelin-targeting bispecific T cell engager (BiTE ® , Amgen trademark)-secr...

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Literature Corpus work: e62ac15b-22bd-5a9b-9575-b6b9bf64422f
DOI: 10.64898/2026.03.26.713601

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